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#1 Prescribed Canine Combination Parasiticide

Available by prescription from your veterinarian.


Our mail-in rebate makes it easy to give your dog effective parasite protection for less.

Save $25 on a year's supply.

Available by prescription from your veterinarian.

Monthly Email Reminder

Email Reminder

Receive an email or text message reminder from your dog when it is time to give Trifexis.

Keep Your Pet Safe

  • Trifexis has demonstrated its safety when used as directed on the label. Learn more.
  • Like all medications, sometimes side effects occur. If you suspect your dog has had an adverse reaction to Trifexis, please call 1-888-545-5973.
  • Find out why choosing Trifexis can protect your dog from fleas, heartworm, and intestinal parasites. Learn more.
Important Safety Information

Serious adverse reactions have been reported following concomitant extra-label use of ivermectin with spinosad alone, one of the components of Trifexis chewable tablets.

Treatment with fewer than three monthly doses after the last exposure to mosquitoes may not provide complete heartworm prevention. Prior to administration of Trifexis, dogs should be tested for existing heartworm infection. Use with caution in breeding females. The safe use of Trifexis in breeding males has not been evaluated. Use with caution in dogs with pre-existing epilepsy.

The most common adverse reactions reported are vomiting, depression/lethargy, itching, decreased appetite, and diarrhea. To ensure heartworm prevention, observe your dog for one hour after administration. If vomiting occurs within an hour of administration, redose with another full dose. Puppies less than 14 weeks of age may experience a higher rate of vomiting.

View full product label for complete safety information.


1. Vet Insite Analytics. Based on total canine combination parasiticide product data (flea, tick, heartworm), 08/2013