Spinosad + Milbemycin Oxime
Trifexis = Spinosad + Milbemycin Oxime
Trifexis® (spinosad + milbemycin oxime) combines two powerful active ingredients that protect your dog safely and effectively against three types of dangerous parasites.
An Eli Lilly scientist discovered spinosad on a beach vacation in the Caribbean. Now, it’s the active ingredient in Trifexis that:
- Starts killing fleas in just 30 minutes—before they can lay eggs
- Killed 100% of fleas in 4 hours in a controlled laboratory study in dogs
- Provides an entire month of full flea protection
Milbemycin oxime is the other active ingredient in Trifexis. It’s a safe way to prevent heartworm disease as well as treat and control adult hookworm*, roundworm and whipworm infections in dogs.
IMPORTANT SAFETY INFORMATION
The use of ivermectin at higher than FDA-approved doses at the same time as Trifexis can result in serious side effects. Treatment with fewer than three monthly doses after the last exposure to mosquitoes may not provide complete heartworm prevention. Prior to administration of Trifexis, dogs should be tested for existing heartworm infection. Use with caution in breeding females. The safe use of Trifexis in breeding males has not been evaluated. Use with caution in dogs with pre-existing epilepsy.
The most common adverse reactions reported are vomiting, depression/lethargy, itching, decreased appetite, and diarrhea. To ensure heartworm prevention, observe your dog for one hour after administration. If vomiting occurs within an hour of administration, redose with another full dose. Puppies less than 14 weeks of age may experience a higher rate of vomiting. Like all medications, keep Trifexis out of reach of children.
View full product label for complete safety information.