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6 Tips For Better Road Trips with Your Dog

5 Ways To Keep Your Dog Active This Winter

10 Tips To Make You a Great Puppy Parent

Share Your Story: Stacy & Finnegan

Share Your Story: Shannon & Lucy Love

Veterinarians and owners recommend Trifexis

Share Your Story: Keith & Cooper

Share Your Story: Hayden & Rufus

How to take better dog photos this holiday season

How much does it cost to raise a dog?

Top four holiday gifts for dogs

Five things you learn as a veterinarian

Dog pills vs topical dog medicine

Share your story: Julie & Bella

Tricks to make Halloween less stressful for your dog

Share your story: Sheila & Crane

Scientific proof that our dogs bring us joy

How to create monthly dosing reminders using Alexa

Your dog needs year-round heartworm prevention

Questions to ask at your dog’s annual exam

Share Your Story: Joshua & Henley

Trust Your Veterinarian Instead of Dr. Google

Seven Ways To Show Your Dog Love

Share Your Story: Bailey & Abigail

How To Get Your Dog To Take Medicine

Share Your Story: Christine & Kelly

Check out these amazing stories

Share Your Story: Adele & Rizo

Tim’s amazing bond with Ringer

A dog agility class is a fun way to spend time with your buddy

Help prevent pets from overheating in cars

Top nine Family-friendly Dog Breeds

Puppy Tip: Reward good behavior

How we Celebrate The Bond with Canine Assistants

Dog park do’s and don’ts

House-training tips for puppies

Preventing parasites vs. treating parasites in dogs

Make sure your dog is protected

Dogs can lower your risk for asthma

10 things your veterinarian wished you knew

Sean’s Fighting Spirit

How does a dog get hookworms?

What does FDA approval mean?

Share Your Story: Laura & Eddie

Put parasites to bed

The whipworm lifecycle in dogs

Share Your Story: Sara & Derby

Is Trifexis® (spinosad + milbemycin oxime) safe for my dog?

How did my dog get fleas?

Understanding the canine heartworm lifecycle

Tips for puppy proofing your home

Five fun outdoor activities to do with your dog

Learn about the roundworm lifecycle in dogs

Heartworm protection for every season

Share Your Story: Kaye & Tessa

Share Your Story: Courtney & Bentley

Why does Trifexis® (spinosad + milbemycin oxime) require a prescription? 

#CelebrateTheBond with this spring’s most popular Facebook posts

Thanks to all the veterinarians, veterinary technicians and staff

3 types of parasite protection. 2 trusted active ingredients. 1 chewable tablet.

Protect what you love

Share Your Story: Amanda & Lou

4 steps to control a flea infestation in your home

Is heartworm prevention important for your dog?

See what happens when incredible dogs and special people form remarkable bonds.
Celebrate the bond with Canine Assistants


The use of ivermectin at higher than FDA-approved doses at the same time as Trifexis can result in serious side effects. Treatment with fewer than three monthly doses after the last exposure to mosquitoes may not provide complete heartworm prevention. Prior to administration of Trifexis, dogs should be tested for existing heartworm infection. Use with caution in breeding females. The safe use of Trifexis in breeding males has not been evaluated. Use with caution in dogs with pre-existing epilepsy.

The most common adverse reactions reported are vomiting, depression/lethargy, itching, decreased appetite, and diarrhea. To ensure heartworm prevention, observe your dog for one hour after administration. If vomiting occurs within an hour of administration, redose with another full dose. Puppies less than 14 weeks of age may experience a higher rate of vomiting. Like all medications, keep Trifexis out of reach of children.

View full product label for complete safety information.