Using Trifexis® (spinosad + milbemycin oxime)

How should I give Trifexis to my dog?

How to give your dog Trifexis® (spinosad + milbemycin oxime)

Give Trifexis with food for maximum effectiveness. Trifexis is a chewable tablet and may be given as if a treat. Consult your veterinarian regarding the need for year round administration of Trifexis. To help you remember the monthly dosing schedule, stick-on labels are included for your calendar.

Do I have to give Trifexis with food?

Administer Trifexis with food for maximum effectiveness.

Can Trifexis tablets be crushed and put in food?

We did not conduct any studies where a crushed Trifexis tablet was added to food and fed to a dog. Given our knowledge of spinosad and milbemycin oxime, it should be stable if the tablet is crushed and consumed right away. The stability in food over any significant period of time, however, cannot be guaranteed. It is best to make sure your dog eats the meal immediately.

The package reads “chewable.” What if my dog swallows the tablet whole?

Given our knowledge of spinosad and milbemycin oxime, Trifexis will be effective if the tablet is consumed in whole (not chewed).

View the dog owner information sheet for Trifexis

What if I give more than the prescribed amount of Trifexis to my dog?

Contact your veterinarian as soon as possible if you believe your dog has ingested more than the recommended dose of Trifexis. In a study in which dogs were dosed at one, three, and five times the upper half of the recommended dose, dogs exhibited vomiting, tremors, decreased activity, salivation, coughing and vocalization.

Should I restrict either my dog’s activity or contact with my dog after the tablet is consumed?

You may maintain normal activities and interactions with your dog.

Does seeing fleas on my dog mean that the treatment is not working?

Trifexis kills fleas before they can lay eggs when used monthly according to the label directions. Remember that all animals in the household should be treated with an approved flea product to help control the flea population. Your dog can continue to be exposed to the fleas that live in the environment. When fleas jump onto and bite your dog, they will be killed by Trifexis. If, within a month after your dog receives Trifexis you see fleas on your dog, they are most likely new fleas. These new fleas will be killed before they can produce eggs that contaminate the environment. Continued monthly use of Trifexis can protect against any new infestations.

What if I see worms in my dog’s stool during the month after administration of Trifexis?

Trifexis is indicated to treat and control intestinal parasite infections of adult hookworms*, roundworms and whipworms. In occasional cases, it is possible that the action of Trifexis in killing the intestinal worms will lead to the dog expelling them in stool. If you have questions, consult with your veterinarian for measures you can take to prevent a reinfection of intestinal parasites.

*Ancylostoma caninum

Can Trifexis be given to cats?

No. Trifexis is not approved for use in cats. Trifexis was developed exclusively for administration to dogs. If you’re looking for Elanco products that are approved for use in cats, learn more on the Elanco brands page