[Dr. Jeff Werber:
Trifexis is a safe, effective monthly tablet that is available from your veterinarian by prescription only. It’s a combination of two active ingredients—spinosad and milbemycin oxime—that have both been approved for use in dogs for many years. In the United States alone, more than 50 million doses of Trifexis have been dispensed through more than 15,000 veterinary clinics like mine.* In fact, many veterinarians around the country have such confidence in the safety and efficacy of Trifexis, they prescribe it for their own dogs.
Trifexis has been shown to be safe for dogs and puppies of all breeds 8 weeks of age or older and weighing 5 pounds or more. This beef-flavored tablet is not only convenient, it’s a smart way to give your dog his monthly preventative. Unlike topicals applied to your dog’s skin, Trifexis can’t be washed off or rubbed onto furniture or clothing. So there’s no need to isolate your dog from children or other pets after treatment.
All products have some risk. It’s important to read the label and understand what the most common adverse reactions that are associated with the drug. If your dog has a reaction to Trifexis, or any drug, report it to the manufacturer or FDA using the phone numbers found on the label. Given as directed, Trifexis is a safe, effective and convenient way to help protect your dog from parasites. If your dog has been using Trifexis successfully, there is no reason to expect that should change.
Ask about Trifexis, the combination product that kills fleas and prevents infestations, prevents heartworm disease, and treats and controls hookworm, roundworm and whipworm infections. See the full product label for complete safety information.
Serious adverse reactions have been reported following concomitant extra-label use of ivermectin with spinosad alone, one of the components of Trifexis. Treatment with fewer than three monthly doses after the last exposure to mosquitoes may not provide complete heartworm prevention. Prior to administration of Trifexis, dogs should be tested for existing heartworm infection. Use with caution in dogs with pre-existing epilepsy.
The most common adverse reactions reported are vomiting, depression/lethargy, pruritus, anorexia, diarrhea, trembling/shaking, ataxia, seizures, hypersalvation and skin reddening. To ensure heartworm prevention, observe your dog for one hour after administration. If vomiting occurs within an hour of administration, redose.
*Vet Insite Analytics. "Based on total canine combination parasiticide product data (flea, tick, heartworm)." Dec. 2015.]