Your Veterinarian, You and Your Dog

What should I discuss with my veterinarian regarding Trifexis® (spinosad + milbemycin oxime) for my dog?

Your veterinarian is your dog’s health care expert and can make the best recommendation about medications for your dog. This includes the prevention, control and/or treatment of parasites such as fleas, heartworms and intestinal parasites that may cause conditions including flea allergy dermatitis, anemia, heart disease and other parasite-related problems. Key points of your discussion may include the following:

  • As with other heartworm preventatives, dogs should be tested for heartworm before beginning treatment with Trifexis.
  • If a dose is missed and/or the monthly interval between doses is exceeded, immediately give Trifexis with food and resume monthly dosing. This practice will minimize the opportunity for heartworms to grow. Also, continuing normal monthly dosing will allow you to gain control of any flea or intestinal parasites (hookworm, roundworm and whipworm) that might have infected your dog.
  • To help minimize the likelihood of fleas continuing to jump onto your dog, it is important to treat all household pets with an approved flea protection product.
  • Like all medications, keep Trifexis out of reach of children. Trifexis is not for use in humans.

Why did my veterinarian prescribe Trifexis?

Your veterinarian prescribed Trifexis to protect your dog from problems that an infection from common parasites can cause. Heartworm infection can make dogs very sick and can even be fatal. Trifexis can prevent flea infestations from becoming established, and can also remove any fleas that are on your dog at the time of treatment. Trifexis will also treat and control common adult intestinal worm infections (hookworms*, roundworms and whipworms).

*Ancylostoma caninum

How can I purchase Trifexis?

Trifexis is a prescription product that should be purchased only from a licensed veterinarian.

Does my dog need a heartworm test before starting Trifexis?

It is important for your veterinarian to assess your dog’s heartworm status prior to initiating a monthly heartworm disease preventative or changing from one brand of preventive to another.

Will my dog still need to be tested for heartworm infection while taking Trifexis?

The American Heartworm Society and Companion Animal Parasite Council (CAPC) recommend annual testing for heartworm infection. You should ask your veterinarian about the recommended frequency of heartworm testing for your dog while taking Trifexis. 1, 2

How do I switch to Trifexis from another heartworm preventative?

Follow the advice of your veterinarian about switching heartworm preventatives.

Can other medications be given while my dog is taking Trifexis?

Yes, Trifexis has been given safely with a wide variety of products and medications. However, there is a label warning that serious adverse reactions have been reported following the use of ivermectin at higher than the FDA-approved dose at the same time as spinosad, one of the components of Trifexis. Your veterinarian should be made aware of all products that you administered and/or intend to administer to your dog.

Can Trifexis be given if my dog has food allergies?

Trifexis contains some hydrolyzed soy and is flavored with artificial beef from a pork-based protein. The amount of hydrolyzed soy in Trifexis is comparable to the amount of the hydrolyzed soy in hypoallergenic diets. If your dog is allergic to soy or pork, you might consider other flea treatment and heartworm and intestinal parasite protection products. Please discuss these options with your veterinarian.

Should I give Trifexis each month all year?

The American Heartworm Society and the Companion Animal Parasite Council (CAPC), an independent group established to create parasite-control guidelines, both recommend treating dogs year-round with  broad-spectrum parasite protection.1,2 However, you should consult your veterinarian regarding specific recommendations. If you do not administer Trifexis monthly throughout the year, continue administering the medication for at least three months following the last exposure to mosquitoes.